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Production of leukemia inhibitory factor by human articular chondrocytes and cartilage in response to interleukin-1 and tumor necrosis factor α

✍ Scribed by Ian K. Campbell; Paul Waring; Ulrike Novak; John A. Hamilton


Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
462 KB
Volume
36
Category
Article
ISSN
0004-3591

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## Abstract ## Objective The protein deacetylase SirT1 positively regulates cartilage‐specific gene expression, while the proinflammatory cytokine tumor necrosis factor α (TNFα) negatively regulates these same genes. This study was undertaken to test the hypothesis that SirT1 is adversely affected