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Tubulin targets in the pathobiology and therapy of glioblastoma multiforme. II. γ-tubulin

✍ Scribed by Christos D. Katsetos; Eduarda Dráberová; Agustin Legido; Pavel Dráber

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
236 KB
Volume
221
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

Glioblastoma multiforme (GBM) is the most common and deadliest form of primary brain cancer in adults. Despite advances in molecular biology and genetics of cancer there is no currently available treatment for these tumors. Aberrant patterns of γ‐tubulin expression and compartmentalization in GBM have been reported lending credence to the assertion that these changes might underlie perturbations in microtubule nucleation and mitosis associated with glioma tumorigenesis and tumor progression. This minireview focuses on the role of γ‐tubulin in the pathobiology of GBM in the light of emerging concepts concerning the function of γ‐tubulin and its potential role in tumorigenesis putting forward the concept that γ‐tubulin might serve as a novel marker of anaplastic change in gliomas. J. Cell. Physiol. 221: 514–520, 2009. © 2009 Wiley‐Liss, Inc.

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