✦ LIBER ✦

Tubulin targets in the pathobiology and therapy of glioblastoma multiforme. I. class III β-tubulin

✍ Scribed by Christos D. Katsetos; Eduarda Dráberová; Agustin Legido; Charles Dumontet; Pavel Dráber

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 625 KB
Volume: 221
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.21870

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Glioblastoma multiforme (GBM) is the most common and deadliest form of primary brain cancer in adults. Despite advances in molecular biology and genetics of gliomas currently there is no effective treatment or promising molecularly targeted experimental therapeutic strategies for these tumors. In previous studies we have shown aberrant overexpression of the class III β‐tubulin isotype (βIII‐tubulin) in GBM and have proposed that this change may reflect perturbations in microtubule dynamics associated with glioma tumorigenesis, tumor progression and malignant transformation into GBM. This minireview focuses on microtubules and tubulin as emerging targets in potential therapy of GBM using a new class of βIII‐tubulin‐targeted drugs in the light of recent developments concerning the function and potential role of this isotype in clinically aggressive tumor behavior, cancer stem cells, tumor hypoxia and chemoresistance to tubulin binding agents, principally taxanes. J. Cell. Physiol. 221: 505–513, 2009. © 2009 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Tubulin targets in the pathobiology and

Tubulin targets in the pathobiology and therapy of glioblastoma multiforme. II. γ-tubulin

✍ Christos D. Katsetos; Eduarda Dráberová; Agustin Legido; Pavel Dráber 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 236 KB

## Abstract Glioblastoma multiforme (GBM) is the most common and deadliest form of primary brain cancer in adults. Despite advances in molecular biology and genetics of cancer there is no currently available treatment for these tumors. Aberrant patterns of γ‐tubulin expression and compartmentalizat

Mutational analysis of the class I β-tub

Mutational analysis of the class I β-tubulin gene in human breast cancer

✍ Seiichi Hasegawa; Yasuo Miyoshi; Chiyomi Egawa; Makoto Ishitobi; Yasuhiro Tamaki 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 244 KB

Non-small cell lung cancers have a high incidence of somatic mutations of the beta-tubulin (class I) gene, suggesting involvement in the acquisition of resistance to taxanes, which exert their effects through binding to beta-tubulin. Since taxanes are often used in the treatment of breast cancer, we

Class III β-Tubulin isotype (β III) in t

Class III β-Tubulin isotype (β III) in the adrenal medulla: III. Differential expression of neuronal and glial antigens identifies two distinct populations of neuronal and glial-like (sustentacular) cells in the PC12 rat pheochromocytoma cell line maintained in a gelfoam matrix system

✍ Katsetos, Christos D. ;Herman, Mary M. ;Balin, Brian J. ;Vinores, Stanley A. ;He 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 755 KB

## Background: The rat PC12 pheochromocytoma cell line provides an established system for the study of neuronal differentiation. To our knowledge, glial differentiation has not been reported in this cell line. Methods: We have studied, by immunohistochemistry and immunoblotting, the presence of n