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[1, 2-Bis(2, 6-difluoro-3-hydroxyphenyl)ethylene-diamine]platinum(II) Complexes, Compounds for the Endocrine Therapy of Breast Cancer - Mode of Action II: Contribution of Drug Inactivation, Cellular Drug Uptake and Sterical Factors in the Drug-Target Interaction to the Antitumor Activity

✍ Scribed by Sabine Schertl; Rolf W. Hartmann; Christine Batzl-Hartmann; Günther Bernhardt; Thilo Spruß; Karin Beckenlehner; Marion Koch; Rudolf Krauser; Richard Schlemmer; Ronald Gust; Helmut Schönenberger

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
167 KB
Volume
337
Category
Article
ISSN
0365-6233

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[1, 2-Bis(2, 6-difluoro-3-hydroxyphenyl)
[1, 2-Bis(2, 6-difluoro-3-hydroxyphenyl)ethylene-diamine]platinum(II) Complexes, Compounds for the Endocrine Therapy of Breast Cancer - Mode of Action I: Antitumor Activity Due to the Reduction of the Endogenous Estrogen Level
✍ Sabine Schertl; Rolf W. Hartmann; Christine Batzl-Hartmann; Günther Bernhardt; T 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 155 KB

## Abstract Aqua[meso‐1, 2‐bis(2, 6‐difluoro‐3‐hydroxyphenyl)ethylenediamine]sulfatoplatinum(II) (meso‐3‐PtSO~4~) and its racemate (rac‐3‐PtSO~4~) are highly active on the hormone‐sensitive MXT‐M‐3, 2 breast cancer of the mouse. __In vitro__, on the MXT^+^ cell culture derived from this tumor, howe