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Tuberous-sclerosis complex-related cell signaling in the pathogenesis of lung cancer

✍ Scribed by Fuchs, Angela; König, Katharina; Heukamp, Lukas C; Fassunke, Jana; Kirfel, Jutta; Huss, Sebastian; Becker, Albert J; Büttner, Reinhard; Majores, Michael

Book ID
125402435
Publisher
BioMed Central
Year
2014
Tongue
English
Weight
791 KB
Volume
9
Category
Article
ISSN
1746-1596

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## Abstract Individuals with tuberous sclerosis complex (TSC) develop central nervous system abnormalities that may reflect astrocyte dysfunction. In an effort to model astrocyte dysfunction in TSC, we generated mice lacking __Tsc1__ (hamartin) expression in astrocytes and demonstrated that __Tsc1_