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T1990 Loss of Tuberous Sclerosis Complex 2 (TSC2) Expression in Cancer Cells Inhibits Cell Migration By Suppressing RAC Activation

✍ Scribed by Larson, Yan; Gao, Tianyan

Book ID
123308954
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
115 KB
Volume
136
Category
Article
ISSN
0016-5085

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## Abstract We investigated the effects of overexpression of the tuberous sclerosis‐1 and ‐2 (__TSC1/2__) gene products (hamartin and tuberin, respectively) in the human kidney epithelial cell line 293 with an inducible expression system. As we had observed previously in fibroblasts, 293 cells over