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SMILE inhibits BMP-2-induced expression of osteocalcin by suppressing the activity of the RUNX2 transcription factor in MC3T3E1 cells

✍ Scribed by Jang, Hoon; Kim, Eun-Jung; Park, Jae-Kyung; Kim, Dong-Ern; Kim, Hyoung-Joo; Sun, Wu-Sheng; Hwang, Seongsoo; Oh, Keon-Bong; Koh, Jeong-Tae; Jang, Won-Gu; Lee, Jeong- Woong


Book ID
122133874
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
679 KB
Volume
61
Category
Article
ISSN
8756-3282

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## Abstract The transcription factor Runx2 can be controlled by a number of upstream regulators involved in intracellular signalling, including the activation ERK1/2 signaling by fibroblast growth factor‐2 (FGF‐2). FGFs interact with their cell surface receptors (FGFRs) through an obligate cross‐bi