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Bone morphogenetic proteins (BMP-2 and BMP-3) induce the late phase expression of the proto-oncogene c-fos in murine osteoblastic MC3T3-E1 cells

✍ Scribed by Shuichi Ohta; Yuji Hiraki; Chohei Shigeno; Fujio Suzuki; Ryuichi Kasai; Toshihiko Ikeda; Hiroaki Kohno; Kaechoong Lee; Haruki Kikuchi; Junji Konishi; Hanne Bentz; David M. Rosen; Takao Yamamuro

Book ID: 115927173
Publisher: Elsevier Science
Year: 1992
Tongue: English
Weight: 548 KB
Volume: 314
Category: Article
ISSN: 0014-5793
DOI: 10.1016/0014-5793(92)81505-g

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## Abstract Interaction between c‐fos and 1,25(OH)~2~ vitamin D~3~ (VD) on the type I collagen synthesis was studied. VD inhibited collagen synthesis and type I collagen mRNA expression in MC3T3‐E1 osteoblastic cells. In contrast, VD reversed the inhibition of collagen synthesis and mRNA expression