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Metformin enhances the differentiation and mineralization of osteoblastic MC3T3-E1 cells via AMP kinase activation as well as eNOS and BMP-2 expression

โœ Scribed by Ippei Kanazawa; Toru Yamaguchi; Shozo Yano; Mika Yamauchi; Toshitsugu Sugimoto

Book ID
116297283
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
294 KB
Volume
375
Category
Article
ISSN
0006-291X

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โœ Ippei Kanazawa; Toru Yamaguchi; Shozo Yano; Mika Yamauchi; Masahiro Yamamoto; To ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› BioMed Central ๐ŸŒ English โš– 897 KB

## Background Adiponectin is a key mediator of the metabolic syndrome that is caused by visceral fat accumulation. Adiponectin and its receptors are known to be expressed in osteoblasts, but their actions with regard to bone metabolism are still unclear. In this study, we investigated the effects o