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The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination

✍ Scribed by Benvenuto, Giovanna; Li, Shaowei; Brown, Samantha J; Braverman, Richard; Vass, William C; Cheadle, Jeremy P; Halley, Dicky JJ; Sampson, Julian R; Wienecke, Ralf; DeClue, Jeffrey E

Book ID: 110064318
Publisher: Nature Publishing Group
Year: 2000
Tongue: English
Weight: 341 KB
Volume: 19
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1204009

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## Abstract We investigated the effects of overexpression of the tuberous sclerosis‐1 and ‐2 (__TSC1/2__) gene products (hamartin and tuberin, respectively) in the human kidney epithelial cell line 293 with an inducible expression system. As we had observed previously in fibroblasts, 293 cells over