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Abnormal Cortical Cells and Astrocytomas in the Eker Rat Model of Tuberous Sclerosis Complex

โœ Scribed by D. Koji Takahashi; Matthew T. Dinday; Nicholas M. Barbaro; Scott C. Baraban

Book ID
110726663
Publisher
Wiley (Blackwell Publishing)
Year
2004
Tongue
English
Weight
250 KB
Volume
45
Category
Article
ISSN
0013-9580

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โœ Okio Hino; Etsuko Kobayashi; Youko Hirayama; Toshiyuki Kobayashi; Yoshiaki Kubo; ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 382 KB

## Abstract We have recently identified on rat chromosome 10q a germline mutation in the tuberous sclerosis gene(__Tsc2__), the gene predisposing to renal carcinoma(a) in the Eker rat. The homozygous mutant condition is lethal at around the 13th day of fetal life. In heterozygotes, RCs invariably d