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Tubal ligation and risk of ovarian cancer in carriers of BRCA1 or BRCA2 mutations: a case-control study

✍ Scribed by Steven A Narod; Ping Sun; Parviz Ghadirian; Henry Lynch; Claudine Isaacs; Judy Garber; Barbara Weber; Beth Karlan; David Fishman; Barry Rosen; Nadine Tung; Susan L Neuhausen


Book ID
117276999
Publisher
The Lancet
Year
2001
Tongue
English
Weight
81 KB
Volume
357
Category
Article
ISSN
0140-6736

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Germline mutations in BRCA1 and BRCA2 are associated with increased risks of breast and ovarian cancer. A genome-wide association study (GWAS) identified six alleles associated with risk of ovarian cancer for women in the general population. We evaluated four of these loci as potential modifiers of