Tubal ligation was associated with a reduced risk of ovarian cancer in BRCA1 mutation carriers
β Scribed by Patricia Hartge
- Book ID
- 117836708
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 68 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1361-259X
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π SIMILAR VOLUMES
Germline mutations in BRCA1 and BRCA2 are associated with increased risks of breast and ovarian cancer. A genome-wide association study (GWAS) identified six alleles associated with risk of ovarian cancer for women in the general population. We evaluated four of these loci as potential modifiers of
## Abstract Dysregulation of apoptosis plays an important role in carcinogenesis. Therefore, apoptosisβassociated genes like the __death receptor 4__ (__DR4, TRAILβR1__) are interesting candidates for modifying the penetrance of breast and ovarian cancer in carriers of __BRCA1__ and __BRCA2__ mutat