Reproductive risk factors for ovarian cancer in carriers of BRCA1 or BRCA2 mutations: a case-control study
β Scribed by John R McLaughlin; Harvey A Risch; Jan Lubinski; Pal Moller; Parviz Ghadirian; Henry Lynch; Beth Karlan; David Fishman; Barry Rosen; Susan L Neuhausen; Kenneth Offit; Noah Kauff; Susan Domchek; Nadine Tung; Eitan Friedman; William Foulkes; Ping Sun; Steven A Narod
- Book ID
- 117784165
- Publisher
- The Lancet
- Year
- 2007
- Tongue
- English
- Weight
- 118 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1470-2045
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Germline mutations in BRCA1 and BRCA2 are associated with increased risks of breast and ovarian cancer. A genome-wide association study (GWAS) identified six alleles associated with risk of ovarian cancer for women in the general population. We evaluated four of these loci as potential modifiers of
## Abstract Early age at first birth and multiparity have been associated with a decrease in the risk of breast cancer in women in the general population. We examined whether this relationship is also present in women at high risk of breast cancer due to the presence of a mutation in either of the