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Tryptophan catabolism generates autoimmune-preventive regulatory T cells

✍ Scribed by Francesca Fallarino; Ursula Grohmann; Sylvaine You; Barbara C. McGrath; Douglas R. Cavener; Carmine Vacca; Ciriana Orabona; Roberta Bianchi; Maria L. Belladonna; Claudia Volpi; Maria C. Fioretti; Paolo Puccetti

Book ID
116940058
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
132 KB
Volume
17
Category
Article
ISSN
0966-3274

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T cell apoptosis by tryptophan catabolis
T cell apoptosis by tryptophan catabolism
✍ Fallarino, F; Grohmann, U; Vacca, C; Bianchi, R; Orabona, C; Spreca, A; Fioretti πŸ“‚ Article πŸ“… 2002 πŸ› Nature Publishing Group 🌐 English βš– 280 KB
T cell apoptosis by tryptophan catabolis
T cell apoptosis by tryptophan catabolism
✍ Fallarino, F; Grohmann, U; Vacca, C; Bianchi, R; Orabona, C; Spreca, A; Fioretti πŸ“‚ Article πŸ“… 2002 πŸ› Nature Publishing Group 🌐 English βš– 280 KB

Indoleamine 2,3-dioxygenase (IDO) is a tryptophan-catabolizing enzyme that, expressed by different cell types, has regulatory effects on T cells resulting from tryptophan depletion in specific local tissue microenvironments. Different mechanisms, however, might contribute to IDO-dependent immune reg