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T cell apoptosis by tryptophan catabolism

โœ Scribed by Fallarino, F; Grohmann, U; Vacca, C; Bianchi, R; Orabona, C; Spreca, A; Fioretti, M C; Puccetti, P

Book ID
110016404
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
280 KB
Volume
9
Category
Article
ISSN
1350-9047

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T cell apoptosis by tryptophan catabolis
T cell apoptosis by tryptophan catabolism
โœ Fallarino, F; Grohmann, U; Vacca, C; Bianchi, R; Orabona, C; Spreca, A; Fioretti ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› Nature Publishing Group ๐ŸŒ English โš– 280 KB

Indoleamine 2,3-dioxygenase (IDO) is a tryptophan-catabolizing enzyme that, expressed by different cell types, has regulatory effects on T cells resulting from tryptophan depletion in specific local tissue microenvironments. Different mechanisms, however, might contribute to IDO-dependent immune reg