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Inhibition of T Cell Proliferation by Macrophage Tryptophan Catabolism

✍ Scribed by Munn, D. H.; Shafizadeh, E.; Attwood, J. T.; Bondarev, I.; Pashine, A.; Mellor, A. L.

Book ID
126047671
Publisher
Rockefeller University Press.
Year
1999
Tongue
English
Weight
175 KB
Volume
189
Category
Article
ISSN
0022-1007

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T cell apoptosis by tryptophan catabolis
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✍ Fallarino, F; Grohmann, U; Vacca, C; Bianchi, R; Orabona, C; Spreca, A; Fioretti πŸ“‚ Article πŸ“… 2002 πŸ› Nature Publishing Group 🌐 English βš– 280 KB

Indoleamine 2,3-dioxygenase (IDO) is a tryptophan-catabolizing enzyme that, expressed by different cell types, has regulatory effects on T cells resulting from tryptophan depletion in specific local tissue microenvironments. Different mechanisms, however, might contribute to IDO-dependent immune reg