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Tryptophan 2,3-dioxygenase is upregulated in the cortex of individuals with schizophrenia

✍ Scribed by C.L. Miller; I.C. Llenos; J.R. Dulay; M.M. Barillo; R.H. Yolken; S. Weis

Book ID
119555687
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
132 KB
Volume
60
Category
Article
ISSN
0920-9964

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Expression of the kynurenine pathway enz
Expression of the kynurenine pathway enzyme tryptophan 2,3-dioxygenase is increased in the frontal cortex of individuals with schizophrenia
✍ Christine L Miller; Ida C Llenos; Jeanette R Dulay; Meliza M Barillo; Robert H Y πŸ“‚ Article πŸ“… 2004 πŸ› Elsevier Science 🌐 English βš– 683 KB

Markers of the kynurenine pathway were studied in postmortem frontal cortex obtained from individuals with schizophrenia and controls. Quantitative endpoint RT-PCR was used to measure mRNA transcripts. Of the two enzymes capable of catalyzing the first step in the pathway, tryptophan 2,3-dioxygenase