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Expression of the kynurenine pathway enzyme tryptophan 2,3-dioxygenase is increased in the frontal cortex of individuals with schizophrenia

โœ Scribed by Christine L Miller; Ida C Llenos; Jeanette R Dulay; Meliza M Barillo; Robert H Yolken; Serge Weis


Book ID
116761570
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
683 KB
Volume
15
Category
Article
ISSN
0969-9961

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Expression of the kynurenine pathway enz
โœ Christine L Miller; Ida C Llenos; Jeanette R Dulay; Meliza M Barillo; Robert H Y ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 683 KB

Markers of the kynurenine pathway were studied in postmortem frontal cortex obtained from individuals with schizophrenia and controls. Quantitative endpoint RT-PCR was used to measure mRNA transcripts. Of the two enzymes capable of catalyzing the first step in the pathway, tryptophan 2,3-dioxygenase