Trypanosoma brucei transferrin receptor can bind C-lobe and N-lobe fragments of transferrin
โ Scribed by Steverding, Dietmar; Sexton, Darren W.; Chrysochoidi, Nektaria; Cao, Fuyun
- Book ID
- 119328513
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 579 KB
- Volume
- 185
- Category
- Article
- ISSN
- 0166-6851
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## Abstract Transferrin (TF) is a bilobal transport protein that acquires ferric iron from the diet and holds it tightly within the cleft of each lobe (thereby preventing its hydrolysis). The iron is delivered to actively dividing cells by receptor mediated endocytosis in which diferric TF preferen
19F NMR was utilitized to study human serum transferrin, which is a bilobal protein with a high-affinity metalbinding site in each lobe. The N-terminal lobe of the recombinant protein (residues 1-337 ; hTF/2N) and three single point mutants, H207E, W8Y and W128Y, were expressed in baby hamster kidne