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Sequential binding of aluminum(3+) to the C- and N-lobes of human serum transferrin detected by proton NMR spectroscopy

โœ Scribed by Kubal, Gina; Sadler, Peter J.; Evans, Robert W.


Book ID
126854867
Publisher
American Chemical Society
Year
1992
Tongue
English
Weight
284 KB
Volume
114
Category
Article
ISSN
0002-7863

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## Abstract Transferrin (TF) is a bilobal transport protein that acquires ferric iron from the diet and holds it tightly within the cleft of each lobe (thereby preventing its hydrolysis). The iron is delivered to actively dividing cells by receptor mediated endocytosis in which diferric TF preferen