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Structural Reorganization of the Transferrin C-Lobe and Transferrin Receptor upon Complex Formation: The C-Lobe Binds to the Receptor Helical Domain †

✍ Scribed by Liu, Rutao; Guan, Jing-Qu; Zak, Olga; Aisen, Philip; Chance, Mark R.


Book ID
127250537
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
675 KB
Volume
42
Category
Article
ISSN
0006-2960

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## Abstract Transferrin (TF) is a bilobal transport protein that acquires ferric iron from the diet and holds it tightly within the cleft of each lobe (thereby preventing its hydrolysis). The iron is delivered to actively dividing cells by receptor mediated endocytosis in which diferric TF preferen