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Trityloxyethylamino group for the protection of phosphoryl group in oligonucleotide synthesis

✍ Scribed by Toshiki Tanaka; Yasuki Yamada; Morio Ikehara

Publisher
Elsevier Science
Year
1986
Tongue
French
Weight
180 KB
Volume
27
Category
Article
ISSN
0040-4039

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✦ Synopsis

Trityloxyethylamino group was used for the protection of 5'-phosphoryl group of deoxyribonucleoside.

This group is not only protecting group of phosphate also the intermediate for the synthesis of d-ppA and d-pppA.

The synthesis of deoxyoligonucleotide with a defined sequence is accomplished very rapidly by either phosphotriester or phosphite-triester approach on a polymer support.

πŸ“œ SIMILAR VOLUMES

The 9-fluorenylmethyloxycarbonyl group a
The 9-fluorenylmethyloxycarbonyl group as a 5β€²-OH protection in oligonucleotide synthesis
✍ Yunxi Ma; Etienne Sonveaux πŸ“‚ Article πŸ“… 1989 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 521 KB

Oligo-DNAs are synthesized on a solid support using the 9-fluorenylmethyloxycarbonyl group as a 5'-OH base labile protection. The synthesis of the pure protected nucleotides, a relevant phosphoramidite-type strategy of coupling, and the optimization of the deprotection steps are described. This new