r e o f P h y s i o l o g i c a l Sciences, S l o v a k Academy o f Sciences, 84216 B r a t i s l a v a , Czechos l o v a k i a . I n s t i t u t e f o r Research, P r o d u c t i o n and A p p l i c a t i o n o f R a d i o i s otopes, R a d i o v h 1, 10227 Prague 10, C z e c h o s l o v a k i a .
Tritium labelling of RAD001—a new rapamycin derivative
✍ Scribed by Th. Moenius; H. Andres; M. Acemoglu; B. Kohler; P. Schnelli; C. Zueger
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- French
- Weight
- 221 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0022-2135
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A potential local anaesthetic, ropivacaine, is synthesized labelled with tritium. The label is introduced by reduction of a racemic tetrahydropyridine derivative with tritium gas. Resolution into the labelled enantiomers is accomplished by preferential crystallization with added carrier. 3H NMR.
## Abstract __Erthro__‐1‐dehydrohexestrol (**4a**), an analog of the nonsteroidal estrogen __meso__‐hexestrol containing a double bond in the side chain, has been synthesized as a general precursor for the preparation of tritium‐labeled hexestrol derivatives. It can be functionalized further as nee
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The use of gamma-irradiated silica gel to promote exchange between tritium (1,2,3) The gas and carbon-bound hydrogen has been previously described.