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Tritium labelling of hexamethyldisiloxane for 3H NMR referencing

✍ Scribed by Mervyn A. Long; John L. Garnett; Christopher A. Lukey

Publisher: John Wiley and Sons
Year: 1979
Tongue: English
Weight: 165 KB
Volume: 12
Category: Article
ISSN: 0749-1581
DOI: 10.1002/mrc.1270120910

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✦ Synopsis

Abstract

Tritium labelled hexamethyldisiloxane is a suitable material for the internal referencing of ^3^H NMR spectra. Such a referencing procedure is necessary where the instrument is not capable of scanning ^1^H resonance under identical experimental conditions. Hexamethyldisiloxane may be tritiated to high activity (typically 1 Ci ml^−1^) by Raney nickel catalysed exchange with elemental tritium in a simple one‐step procedure. A variety of heterogeneous catalysts are shown to be inactive in the common labelling method involving exchange with tritiated water.

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