𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Tritiated peptides. Part 161. Synthesis of [3H-Tyr8]-physalaemin

✍ Scribed by D. E. Brundish; R. Wade

Book ID
102373616
Publisher
John Wiley and Sons
Year
1986
Tongue
French
Weight
485 KB
Volume
23
Category
Article
ISSN
0022-2135

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✦ Synopsis

The title compound was synthesised with a specific activity o f 30 Ci mmol-' and with radiochemical purity of 96% by iodination of the sulphoxide followed by catalytic tritiation of an isolated fraction. Iodination and reduction studies on model peptides are reported. Alternative philosophies for preparing tritiated peptides are critically discussed.

📜 SIMILAR VOLUMES

Synthesis of /Tyr-3H/4-angiotensin II an
Synthesis of /Tyr-3H/4-angiotensin II and /Phe-3H/8-angiotensin II via halogen-derivatives of angiotensin II
✍ I. Mezõ; J. A. Seproõi; I. Teplán; J. L. Morgat; P. Fromageot; G. Tóth; F. Sirok 📂 Article 📅 1978 🏛 John Wiley and Sons 🌐 French ⚖ 369 KB

## Abstract A method is described for the tritium labelling of angiotensin II in two different positions. /Tyr‐^3^H/^4^‐angiotensin II and /Phe‐^3^H/^8^‐angiotensin II of high specific radioactivity have been prepared starting from Dbt^4^‐angiotensin II and Cpa^8^‐angiotensin II, respectively.

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A potentially general synthesis of high specific activity specifically labelled tritiated peptides: Synthesis of [D-3-(2-naphthyl)-[2,3-3H]alanine6]LHRH
✍ Howard Parnes; Emma J. Shelton 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 French ⚖ 623 KB

High specific activity (43.7 Ci/mmol) D-3-(2-naphthyl)- [ 2,3, -3H]alanine (l) was obtained by reduction of methyl 2-N-acetylamino-3-(2-naphthyl)acrylate (5) with carrier free tritium in the presence of (Ph3P)3RhCl followed by enzymatic resolution and hydrolysis. Reductions of 5. and other substrat