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Tritiated peptides. 12. Synthesis and biological activity of [4-3H-Phe8]substance P

✍ Scribed by Allen, Mark C.; Brundish, Derek E.; Wade, Roy; Sandberg, Bengt E. B.; Hanley, Michael R.; Iversen, Leslie L.


Book ID
126154302
Publisher
American Chemical Society
Year
1982
Tongue
English
Weight
756 KB
Volume
25
Category
Article
ISSN
0022-2623

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High specific activity (43.7 Ci/mmol) D-3-(2-naphthyl)- [ 2,3, -3H]alanine (l) was obtained by reduction of methyl 2-N-acetylamino-3-(2-naphthyl)acrylate (5) with carrier free tritium in the presence of (Ph3P)3RhCl followed by enzymatic resolution and hydrolysis. Reductions of 5. and other substrat