Tritiated hexadecyl platelet activating factor (PAF)
β Scribed by Steven D. Wyrick; Judy S. McClanahan; Robert L. Wykle; Joseph T. O'Flaherty
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- French
- Weight
- 259 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0022-2135
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π SIMILAR VOLUMES
The synthesis of the five-membered cyclic phosphorodiamidic-acid derivatives 10 and 11 as well as the preparation of the six-membered cyclic phosphates 18, 19,22-25, and phosphoramidates 27-32 is described. The effects of these conformationally restricted platelet-activating factor analogs on rabbit
Platelet-activating factor (PAF) is an autacoid derived from cellular membrane phospholipids in response to chemical or physical stimuli. It has been identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphocholine; the alkyl group is composed of 16 or 18 carbon atoms in human cells. PAF can cause a se
## Abstract Plateletβactivating factor (1β__O__βalkylβ2βacetylβ__sn__βglyceroβ3βphosphorylcholine; PAF) is a very potent phospholipid, which has been demonstrated to stimulate smooth muscle and change vascular permeability. PAF has been detected in the rabbit preimplantation uterine endometrium and
The failure of normal human platelets to aggregate in response to platelet activating factor (PAF) has not been previously observed. We report here the first case of a patient whose platelets did not aggregate to PAF on multiple occasions.