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Tritiated hexadecyl platelet activating factor (PAF)

✍ Scribed by Steven D. Wyrick; Judy S. McClanahan; Robert L. Wykle; Joseph T. O'Flaherty


Publisher
John Wiley and Sons
Year
1985
Tongue
French
Weight
259 KB
Volume
22
Category
Article
ISSN
0022-2135

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Platelet-activating factor (PAF) is an autacoid derived from cellular membrane phospholipids in response to chemical or physical stimuli. It has been identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphocholine; the alkyl group is composed of 16 or 18 carbon atoms in human cells. PAF can cause a se

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## Abstract Platelet‐activating factor (1‐__O__‐alkyl‐2‐acetyl‐__sn__‐glycero‐3‐phosphorylcholine; PAF) is a very potent phospholipid, which has been demonstrated to stimulate smooth muscle and change vascular permeability. PAF has been detected in the rabbit preimplantation uterine endometrium and

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The failure of normal human platelets to aggregate in response to platelet activating factor (PAF) has not been previously observed. We report here the first case of a patient whose platelets did not aggregate to PAF on multiple occasions.