Platelet activating factor (PAF) andlyso-PAF in psoriasis
β Scribed by M. R. Judge; R. M. Barr; A. I. Mallet; F. Courtney; A. Kobza Black; M. W. Greaves
- Publisher
- Springer-Verlag
- Year
- 1994
- Tongue
- English
- Weight
- 409 KB
- Volume
- 286
- Category
- Article
- ISSN
- 0340-3696
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## Abstract Plateletβactivating factor (1β__O__βalkylβ2βacetylβ__sn__βglyceroβ3βphosphorylcholine; PAF) is a very potent phospholipid, which has been demonstrated to stimulate smooth muscle and change vascular permeability. PAF has been detected in the rabbit preimplantation uterine endometrium and
Platelet-activating factor (PAF) is an autacoid derived from cellular membrane phospholipids in response to chemical or physical stimuli. It has been identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphocholine; the alkyl group is composed of 16 or 18 carbon atoms in human cells. PAF can cause a se
The synthesis of the five-membered cyclic phosphorodiamidic-acid derivatives 10 and 11 as well as the preparation of the six-membered cyclic phosphates 18, 19,22-25, and phosphoramidates 27-32 is described. The effects of these conformationally restricted platelet-activating factor analogs on rabbit
## Abstract Quantitative hapten inhibition experiments employing sheep antiβPAF antibodies and selected PAF analogues were undertaken with the aim of defining the antigenic determinant structures complementary to the antibody combining sites. The most important fine structural features for inhibiti