## Abstract A female patient with chronic myelocytic leukemia (CML) in chronic phase after busulfan and interferon treatment had four different cell lines in her bone marrow. In addition to cells with a normal karyotype there were cells with the Philadelphia chromosome (Ph^1^), cells with trisomy 8
✦ LIBER ✦
Trisomy X in Philadelphia chromosome–negative cells during the course of Philadelphia chromosome–positive chronic myelocytic leukemia
✍ Scribed by Asahi Hishida; Kazuhito Yamamoto; Tadashi Matsushita; Mitsune Tanimoto; Hidehiko Saito; Nobuhiko Emi
- Book ID
- 114135524
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 85 KB
- Volume
- 142
- Category
- Article
- ISSN
- 0165-4608
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## Abstract ## BACKGROUND Anecdotal cases of chromosomal abnormalities in Philadelphia chromosome (Ph)‐negative metaphases have been reported in patients with chronic myelogenous leukemia (CML) in the chronic phase during treatment with interferon and, more recently, with imatinib. This phenomenon