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Trisomy 8 in philadelphia chromosome (ph1)-negative cells in the course of ph1-positive chronic myelocytic leukemia

✍ Scribed by Monica Casali; Fabrizio Truglio; Emanuela Maserati; Francesco Pasquali; Giuseppe Milone; Francesco Di Raimondo; Gisella Parrinello

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 196 KB
Volume: 4
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870040314

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✦ Synopsis

Abstract

A female patient with chronic myelocytic leukemia (CML) in chronic phase after busulfan and interferon treatment had four different cell lines in her bone marrow. In addition to cells with a normal karyotype there were cells with the Philadelphia chromosome (Ph^1^), cells with trisomy 8 and a Ph^1^, and cells with trisomy 8 as the sole anomaly.

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