Trisomy 12 in uterine leiomyomas: A new cytogenetic subgroup
✍ Scribed by Mef Nilbert; Sverre Heim; Nils Mandahl; Ulla-Maria Flodérus; Helena Willén; Felix Mitelman
- Book ID
- 119104593
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 170 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0165-4608
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Our cytogenetic findings in 175 uterine leiomyomas revealed 52 tumors with clonal chromosome abnormalities, eight of which did not belong to any well-delineated cytogenetic abnormal subgroup. However, an interstitial deletion of the long arm of chromosome 3 was found, as the sole chromosome abnormal
Uterine leiomyomas are benign tumors that arise clonally from smooth muscle cells of the myometrium. Cytogenetic studies of uterine leiomyomas have shown that about 40% have chromosome abnormalities and that deletion of 7q is a common finding. The observations suggest the possible location of a grow