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Trimethylsilyl chloride/tetramethylethylenediamine facilitated additions of organocopper reagents (RCu) to enones

โœ Scribed by Carl R. Johnson; Thomas J. Marren


Book ID
108382809
Publisher
Elsevier Science
Year
1987
Tongue
French
Weight
241 KB
Volume
28
Category
Article
ISSN
0040-4039

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1,4-Additions of the highly functionaliz
โœ Ming Chang P. Yeh; Paul Knochel; William M. Butler; Scott C. Berk ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 208 KB

The new copper reagents RCu(CN)Zn I .2 BF3 1 containing various functional groups like esters, cyanides, chlorides or enoates react with p, P'-disubstituted enones to afford the Michael adducts 4-7 in high yields (81-98%). Cyano-substituted 1,4-adducts undergo a new cyclization reaction leading to t