The unique hereditary enamel defect clearly related to the disturbance of one enamel matrix protein is X-linked amelogenesis imperfecta (AI), in which several mutations of amelogenin gene have been identified. The clinical phenotype of many of these subjects shows similarities with enamel defects re
Triiodothyronine (T3) and 1,25-dihydroxyvitamin D3 (1,25D3) Inversely Regulate OPG Gene Expression in Dependence of the Osteoblastic Phenotype
โ Scribed by F. Varga; S. Spitzer; K. Klaushofer
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 186 KB
- Volume
- 74
- Category
- Article
- ISSN
- 1432-0827
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The vitamin D receptor (VDR) is a nuclear receptor that mediates the effect of the active metabolite of vitamin D3, the 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3). To investigate the potential role of this hormone in the peripheral nervous system, we have studied the VDR expression in Schwann cells. Th
Though extensive studies have been conducted, questions regarding the molecular effectors and pathways underlying the regulatory role of 1,25(OH) 2 D 3 in human osteoblasts other than cell differentiation and matrix protein production remain unanswered. This study aims to identify genes and pathways