The effect of microgravity on 1,25-dihydroxyvitamin d3signalling in osteoblasts
β Scribed by Lieve Coenegrachts; Ingrid Stockmans; Ilse Segers; Roger Bouillon; Geert Carmeliet
- Publisher
- Springer Netherlands
- Year
- 2007
- Tongue
- English
- Weight
- 156 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0938-0108
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## Abstract Cells experience a variety of physiological and nonβphysiological stresses and consequently have appropriate mechanisms to deal with such deviations from homeostasis. Particularly subject to mechanical stress and shear forces are the cells that make up the bones. Osteoblastic cells can
la,25-Dihydroxyvitamin D3 (1 a,25-(OH),D3) has been shown to increase cytosolic calcium and inositol triphosphate levels in rat osteosarcoma cells (ROS 17/23) and to increase nuclear calcium in these cells. To determine the mechanism(s) of Ia,25-(OH),D3-induced changes in nuclear calcium, the effect