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Trifluoromethylated Quinolines

โœ Scribed by Mooradian, Aram.; Suter, C. M.


Book ID
126941216
Publisher
American Chemical Society
Year
1949
Tongue
English
Weight
233 KB
Volume
71
Category
Article
ISSN
0002-7863

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4-(Trifluoromethyl)quinoline Derivatives
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## Abstract Under carefully controlled conditions, ethyl 4,4,4โ€trifluoroacetoacetate (ethyl 4,4,4โ€trifluoroโ€3โ€oxobutanoate) can be condensed with anilines and subsequently cyclized to give 4โ€trifluoromethylโ€2โ€quinolinones **1** although only in poor yield. Heating these products with phosphoryl tri

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Tritluoromethyl substituted quinolines have been prepared by 1,2-or 1,4-addition of anilines to trifluoroacetyl acetylenes followed by intramolecular acid catalyzed ring closure. Recently considerable interest has been dimcted toward the synthesis of trifluorometbyl substituted heteroaromatic compo

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โœ Sarojini, B. K. ;Narayana, B. ;Mayekar, Anil N. ;Yathirajan, H. S. ;Bolte, Micha ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› International Union of Crystallography ๐ŸŒ English โš– 350 KB

In the title compound, C~11~H~5~F~6~NOยทC~11~H~5~F~6~NO, both molecules (except F and H atoms) are essentially planar (the r.m.s. deviations for all non-H atoms are 0.008 and 0.034โ€…ร… for the alcohol and ketone, respectively). The two molecules are connected by an Oโ€”H...O hydrogen bond. The protonated