Trifluoromethylated Quinolines
โ Scribed by Mooradian, Aram.; Suter, C. M.
- Book ID
- 126941216
- Publisher
- American Chemical Society
- Year
- 1949
- Tongue
- English
- Weight
- 233 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0002-7863
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract Under carefully controlled conditions, ethyl 4,4,4โtrifluoroacetoacetate (ethyl 4,4,4โtrifluoroโ3โoxobutanoate) can be condensed with anilines and subsequently cyclized to give 4โtrifluoromethylโ2โquinolinones **1** although only in poor yield. Heating these products with phosphoryl tri
Tritluoromethyl substituted quinolines have been prepared by 1,2-or 1,4-addition of anilines to trifluoroacetyl acetylenes followed by intramolecular acid catalyzed ring closure. Recently considerable interest has been dimcted toward the synthesis of trifluorometbyl substituted heteroaromatic compo
In the title compound, C~11~H~5~F~6~NOยทC~11~H~5~F~6~NO, both molecules (except F and H atoms) are essentially planar (the r.m.s. deviations for all non-H atoms are 0.008 and 0.034โ ร for the alcohol and ketone, respectively). The two molecules are connected by an OโH...O hydrogen bond. The protonated