4-(Trifluoromethyl)quinoline Derivatives
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Olivier Lefebvre; Marc Marull; Manfred Schlosser
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Article
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2003
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John Wiley and Sons
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English
⚖ 137 KB
## Abstract Under carefully controlled conditions, ethyl 4,4,4‐trifluoroacetoacetate (ethyl 4,4,4‐trifluoro‐3‐oxobutanoate) can be condensed with anilines and subsequently cyclized to give 4‐trifluoromethyl‐2‐quinolinones **1** although only in poor yield. Heating these products with phosphoryl tri