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4-(Trifluoromethyl)quinoline Derivatives.

✍ Scribed by Olivier Lefebvre; Marc Marull; Manfred Schlosser


Book ID
101941919
Publisher
John Wiley and Sons
Year
2003
Weight
166 KB
Volume
34
Category
Article
ISSN
0931-7597

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4-(Trifluoromethyl)quinoline Derivatives
✍ Olivier Lefebvre; Marc Marull; Manfred Schlosser 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 137 KB

## Abstract Under carefully controlled conditions, ethyl 4,4,4‐trifluoroacetoacetate (ethyl 4,4,4‐trifluoro‐3‐oxobutanoate) can be condensed with anilines and subsequently cyclized to give 4‐trifluoromethyl‐2‐quinolinones **1** although only in poor yield. Heating these products with phosphoryl tri