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Trifluoromethyl ketones derived from squalene: inhibition of the cholesterol biosynthesis in HepG2 cells

✍ Scribed by Farid Benayoud; Ahmed Abouabdellah; Cyrille Richard; Danièle Bonnet-Delpon; Jean-Pierre Bégué; Danielle Levasseur; Olivier Boutaud; Francis Schuber

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
154 KB
Volume
41
Category
Article
ISSN
0040-4039

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✦ Synopsis

Tri¯uoromethyl ketones 1 and 2, have been prepared from trisnorsqualene aldehyde 3. These compounds and their corresponding alcohols 4 and 7 have been found to be good inhibitors of the biosynthesis of cholesterol in HepG2 cells. The inhibition is correlated with a decrease of the HMG-CoA reductase activity, probably resulting from the transformation of the ¯uorinated compounds into their corresponding oxysterols which could act as repressors of that enzyme.

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