✦ LIBER ✦
The biosynthesis of derivatives of allylic alcohols from [2-14C] mevalonate in liver enzyme preparations and their relation to synthesis of squalene
✍ Scribed by G. Popják
- Publisher
- Elsevier Science
- Year
- 1959
- Tongue
- French
- Weight
- 497 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
STUDIES on the enzymic synthesis of squalene from mevalonic acid (3:5dihydroxy-j-methylpentanoic acid) in yeast extracts have revealed a number of nei intermediates. 5-Phosphomevalonate,1'2'3 54iphosphomevalonate and 3-methylbut-J-en-l;yl. pyrophosphate (isopentenyl pyrophosphate) 4,5,6 have been recognized as successive intermediates in the synthesis of squalene.
Iti,,edditiop, Lynen et al, 5 found that a protein fraction of yeast extracts catalysed the synthesis from mevalonate of fexnesyl pyrophosphate which was 1 T. T. Tchen, J. Amer. Chem. Sot, 14, (1957).