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Trifluopromazine Late Preventive Effects on Carbon Tetrachloride-Induced Liver Necrosis

✍ Scribed by E.C. de Ferreyra; A.S. Bernacchi; M.F. San Martin; G.D. Castro; J.A. Castro

Book ID
112243866
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
607 KB
Volume
62
Category
Article
ISSN
0014-4800

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Imipramine administration (50 mg kg-1, i.p.) to Sprague-Dawley male rats (240-290 g) 6 or 10 h after CCl4 (1 ml kg-1, i.p.) partially prevents liver necrosis induced by the hepatotoxin. When imipramine is given 30 min before CCl4, it inhibits in part the CCl4-induced lipid peroxidation and the coval