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Late preventive effects of trifluoperazine on carbon tetrachloride-induced hepatic necrosis

✍ Scribed by M.C. Villarruel; G. Fernández; E.C. de Ferreyra; O.M. de Fenos; J.A. Castro

Book ID
113206775
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
578 KB
Volume
83
Category
Article
ISSN
0041-008X

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Imipramine prevention of carbon tetrachl
Imipramine prevention of carbon tetrachloride-induced liver necrosis at late states of the intoxication process
✍ G. Fernández; M. C. Villarruel; E. C. de Ferreyra; O. M. de Fenos; J. A. Castro 📂 Article 📅 1986 🏛 John Wiley and Sons 🌐 English ⚖ 684 KB

Imipramine administration (50 mg kg-1, i.p.) to Sprague-Dawley male rats (240-290 g) 6 or 10 h after CCl4 (1 ml kg-1, i.p.) partially prevents liver necrosis induced by the hepatotoxin. When imipramine is given 30 min before CCl4, it inhibits in part the CCl4-induced lipid peroxidation and the coval