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Mechanism of chlorpromazine prevention of carbon tetrachloride-induced liver necrosis

✍ Scribed by Adriana Marzi; Edith G.D. de Toranzo; JoséA. Castro

Book ID
116072694
Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
548 KB
Volume
52
Category
Article
ISSN
0041-008X

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Imipramine administration (50 mg kg-1, i.p.) to Sprague-Dawley male rats (240-290 g) 6 or 10 h after CCl4 (1 ml kg-1, i.p.) partially prevents liver necrosis induced by the hepatotoxin. When imipramine is given 30 min before CCl4, it inhibits in part the CCl4-induced lipid peroxidation and the coval