Triethylene glycol dimethacrylate induces large deletions in the hprt gene of V79 cells
β Scribed by Helmut Schweikl; Gottfried Schmalz
- Book ID
- 117767724
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 80 KB
- Volume
- 438
- Category
- Article
- ISSN
- 1383-5718
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In the present study the carcinogenic metal ions Cd [II], Co [II], Cr [VI], Ni [II], and Pb [II], as well as As[III], were examined for their ability to induce intrachromosomal homologous and nonhomologous recombination in the hprt gene of two V79 Chinese hamster cell lines, SPD8 and Sp5, respective
Spontaneous phenotypic revertants of hypoxanthine phosphoribosyl-transferase (HPRT) temperature-sensitive V79 Chinese hamster cells were selected by plating a temperature-sensitive mutant in HAT medium at 39OC. The incidence of such revertants was approximately 2 x per cell. The majority of the reve