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Gene amplification as a mechanism of reversion at the HPRT locus in V79 chinese hamster cells

โœ Scribed by Olga Zownir; James C. Fuscoe; Raymond Fenwick; John Morrow

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
984 KB
Volume
119
Category
Article
ISSN
0021-9541

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โœฆ Synopsis

Spontaneous phenotypic revertants of hypoxanthine phosphoribosyl-transferase (HPRT) temperature-sensitive V79 Chinese hamster cells were selected by plating a temperature-sensitive mutant in HAT medium at 39OC. The incidence of such revertants was approximately 2 x per cell. The majority of the revertants examined had increases of between three-and tenfold in their specific activity of the enzyme, and they were able to grow continuously

๐Ÿ“œ SIMILAR VOLUMES

Arsenic[III] and heavy metal ions induce
Arsenic[III] and heavy metal ions induce intrachromosomal homologous recombination in the hprt gene of V79 Chinese hamster cells
โœ Thomas Helleday; Robert Nilsson; Dag Jenssen ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 106 KB ๐Ÿ‘ 2 views

In the present study the carcinogenic metal ions Cd [II], Co [II], Cr [VI], Ni [II], and Pb [II], as well as As[III], were examined for their ability to induce intrachromosomal homologous and nonhomologous recombination in the hprt gene of two V79 Chinese hamster cell lines, SPD8 and Sp5, respective