Trend for an association between schizophrenia and D3S1310, a marker in proximity to the dopamine D3 receptor gene

✍ Scribed by J�nsson, E.G.; Nimgaonkar, V.L.; Zhang, X.R.; Shaw, S.H.; Burgert, E.; Crocq, M.-A.; Chakravarti, A.; Sedvall, G.C.

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 22 KB
• Volume: 88
• Category: Article
• ISSN: 0148-7299
• DOI: 10.1002/(sici)1096-8628(19990820)88:4<352::aid-ajmg12>3.0.co;2-0

✦ Synopsis

There is considerable controversy regarding a putative association between schizophrenia and a biallelic BalI polymorphism in the first exon of the dopamine D3 receptor gene (DRD3), although meta-analyses of published data suggest an association. If such an association exists, it may be detectable at markers physically close to DRD3. Accordingly, we conducted a case-control association study using D3S1310, a short tandem repeat polymorphism located approximately 700 kb telomeric to DRD3 on chromosome 3q13.3. The subjects were Swedish patients with schizophrenia (DSM III-R criteria, n = 110) and screened adult controls (n = 83). A trend for a negative association with the 141 bp allele was detected ( 2 = 7.6, d.f. = 1, P = 0.006; odds ratio 0.46, 95% confidence intervals 0.26, 0.81). However, following corrections for multiple comparisons using subgroups (n = 15) the difference was not significant. Also, due to the risk for population stratification in case-control association studies the results must be treated as tentative. If replicated the results may lend further support for the proposition of an association between schizophrenia and DRD3 or a gene in close