✦ LIBER ✦

Association between novelty-seeking and the dopamine D3 receptor gene in bipolar patients: A preliminary report

✍ Scribed by Staner, L.; Hilger, C.; Hentges, F.; Monreal, J.; Hoffmann, A.; Couturier, M.; Le Bon, O.; Stefos, G.; Souery, D.; Mendlewicz, J.

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 15 KB
Volume: 81
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(19980328)81:2<192::aid-ajmg12>3.0.co;2-c

No coin nor oath required. For personal study only.

✦ Synopsis

Recent studies in healthy controls

suggest an association between novelty-seeking (NS) and the dopamine D4 receptor (DRD4) gene. In this study, we further investigated the relationship between genes implicated in dopamine as well as serotonin neurotransmission and personality traits in bipolar (BP) disorder. Scores on the Tridimensional Personality Questionnaire were examined in 37 recovered Research Diagnostic Criteria-diagnosed BP patients genotyped for DRD3, DRD4, and serotonin 2A receptor (5HTR2a) polymorphisms. Carriers of DRD3 allele 1 showed significantly lower NS values compared to patients without this allele. Scores on NS and on harm-avoidance were not related to DRD4 or 5HTR2a polymorphisms. These preliminary results suggest a role for D3 receptor in NS expression in BP patients. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 81:192-194, 1998.

📜 SIMILAR VOLUMES

Trend for an association between schizop

Trend for an association between schizophrenia and D3S1310, a marker in proximity to the dopamine D3 receptor gene

✍ J�nsson, E.G.; Nimgaonkar, V.L.; Zhang, X.R.; Shaw, S.H.; Burgert, E.; Crocq, M. 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 22 KB 👁 1 views

There is considerable controversy regarding a putative association between schizophrenia and a biallelic BalI polymorphism in the first exon of the dopamine D3 receptor gene (DRD3), although meta-analyses of published data suggest an association. If such an association exists, it may be detectable a

Novelty seeking traits and D4 dopamine r

Novelty seeking traits and D4 dopamine receptors

✍ Swift, Geraldine; Larsen, Brian; Hawi, Ziarih; Gill, Michael 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 5 KB

Association between dopamine D4 receptor

Association between dopamine D4 receptor (D4DR) Exon III polymorphism and novelty seeking in Japanese subjects

✍ Ono, Yutaka; Manki, Hiroshi; Yoshimura, Kimio; Muramatsu, Taro; Mizushima, Hirok 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 13 KB 👁 1 views

This study was designed to assess the association between novelty seeking and D4DR gene polymorphism in the Japanese population. The 48 bp repeat polymorphism in the third exon of the dopamine D4 receptor gene of 153 normal female students was correlated with personality feature results from the Jap

Association between novelty seeking and

Association between novelty seeking and dopamine receptor D4 (DRD4) exon III polymorphism in Japanese subjects

✍ Tomitaka, Midori; Tomitaka, Shin-ichiro; Otuka, Yoshiko; Kim, Keiko; Matuki, Hid 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 10 KB

In this study, we investigated the association between dopamine receptor D4 (DRD4) exon III polymorphism and novelty seeking in 69 Japanese women. The group of subjects with long allele (≥ ≥ ≥ 5 repeats) exhibited significantly elevated novelty seeking scores in comparison with subjects lacking the

Human novelty-seeking personality traits

Human novelty-seeking personality traits and dopamine D4 receptor polymorphisms: a twin and genetic association study

✍ Pogue-Geile, Michael; Ferrell, Robert; Deka, Ranjan; Debski, Thomas; Manuck, Ste 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 29 KB 👁 1 views

Although it is well-established that genetic variation is important in causing individual differences in many human personality traits or based on family, twin, and adoption studies, the first reports that specific genetic polymorphisms might influence a normal dimension of personality were only rec

Dopamine D3 receptor gene: Organization,

Dopamine D3 receptor gene: Organization, transcript variants, and polymorphism associated with schizophrenia

✍ Griffon, N.; Crocq, M. A.; Pilon, C.; Martres, M. P.; Mayerova, A.; Uyanik, G.; 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 49 KB 👁 2 views

DNA fragments from a genomic library were used to establish the partial structure of the human dopamine D3 receptor gene (DRD3). Its coding sequence contains 6 exons and stretches over 40,000 base pairs. The complete DRD3 transcript and three shorter variants, in which the second andor third exon ar