Although it is well-established that genetic variation is important in causing individual differences in many human personality traits or based on family, twin, and adoption studies, the first reports that specific genetic polymorphisms might influence a normal dimension of personality were only rec
Novelty seeking traits and D4 dopamine receptors
โ Scribed by Swift, Geraldine; Larsen, Brian; Hawi, Ziarih; Gill, Michael
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 5 KB
- Volume
- 96
- Category
- Article
- ISSN
- 0148-7299
- DOI
- 10.1002/(sici)1096-8628(20000403)96:2<222::aid-ajmg18>3.0.co;2-b
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The relationship of various dimensions of temperament, measured by the Tridimensional Personality Questionnaire (TPQ), to polymorphisms of the D2 dopamine receptor (DRD2) and D4 dopamine receptor (DRD4) genes was determined in 119 healthy Caucasian boys who had not yet begun to consume alcohol and o
A dysfunction of dopaminergic neurotansmission has been implicated in alcoholseeking behavior. Recently, a significant association between the seven-repeat allele (DRD4\*7R) of a 16 amino acid motif in the third exon of the dopamine D4 receptor gene (DRD4) and the personality trait of novelty seekin
Activation of the mesolimbic dopamine pathway appears to promote drug-and alcohol-seeking behavior in laboratory animals. Results for association and linkage analysis between various alcohol dependence phenotypes and the dopamine receptors have been quite mixed. Similarly, both positive and negative
This study was designed to assess the association between novelty seeking and D4DR gene polymorphism in the Japanese population. The 48 bp repeat polymorphism in the third exon of the dopamine D4 receptor gene of 153 normal female students was correlated with personality feature results from the Jap
In this study, we investigated the association between dopamine receptor D4 (DRD4) exon III polymorphism and novelty seeking in 69 Japanese women. The group of subjects with long allele (โฅ โฅ โฅ 5 repeats) exhibited significantly elevated novelty seeking scores in comparison with subjects lacking the