Dopamine D1 receptor gene polymorphism and schizophrenia in Japan

✍ Scribed by Kojima, Hideki; Ohmori, Osamu; Shinkai, Takahiro; Terao, Takeshi; Suzuki, Takashi; Abe, Kazuhiko

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 21 KB
• Volume: 88
• Category: Article
• ISSN: 0148-7299
• DOI: 10.1002/(sici)1096-8628(19990416)88:2<116::aid-ajmg3>3.0.co;2-y

✦ Synopsis

We studied the relationship between schizophrenia and the DdeI polymorphism in the 5 untranslated region (5UTR) of the dopamine D1 receptor (DRD1) gene. This polymorphism is an A (A1 allele) to G (A2 allele) transition in the 5 UTR of exon 2 at bp -48 (A-48G). One hundred forty-eight schizophrenics and 148 control subjects were investigated. No significant differences in genotypic counts and allele frequencies between schizophrenics and controls were found. Although a significant difference between the patients classified as disorganized type and the controls was discovered both in genotypic counts and allele frequencies, neither association proved significant when a Bonferroni correction was used. Moreover, there were no differences in scores of main symptoms of schizophrenia based on the Manchester Scale between patients with A1/A1 genotype and those with A1/A2 genotype. These findings suggest that this gene may not be involved in the pathogenesis of schizophrenia. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 88:116-119, 1999.