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TREM2 R47H Variant as a Risk Factor for Early-Onset Alzheimer's Disease

✍ Scribed by Pottier, Cyril ;Wallon, David ;Rousseau, Stephane ;Rovelet-Lecrux, Anne ;Richard, Anne-Claire ;Rollin-Sillaire, Adeline ;Frebourg, Thierry ;Campion, Dominique ;Hannequin, Didier ;,


Book ID
121686128
Publisher
IOS Press
Year
2013
Tongue
English
Weight
63 KB
Volume
35
Category
Article
ISSN
1387-2877

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ApoE genotype is a risk factor in nonpre
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The apolipoprotein E (ApoE) genotype is a significant risk factor and modulator of age of onset of Alzheimer's disease (AD). We analyzed the effect of the ApoE genotype in two distinct early-onset familial AD groups: families with a mutation in the presenilin-1 gene (PS-1) on chromosome 14, and fami