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ABCA2 is a strong genetic risk factor for early-onset Alzheimer's disease

✍ Scribed by Sandrine Macé; Emmanuelle Cousin; Sylvain Ricard; Emmanuelle Génin; Emmanuel Spanakis; Carole Lafargue-Soubigou; Bérengère Génin; Raphaël Fournel; Sandrine Roche; Gilles Haussy; Florence Massey; Stéphane Soubigou; Georges Bréfort; Patrick Benoit; Alexis Brice; Dominique Campion; Melvyn Hollis; Laurent Pradier; Jésus Benavides; Jean-François Deleuze


Book ID
116761689
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
231 KB
Volume
18
Category
Article
ISSN
0969-9961

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The apolipoprotein E (ApoE) genotype is a significant risk factor and modulator of age of onset of Alzheimer's disease (AD). We analyzed the effect of the ApoE genotype in two distinct early-onset familial AD groups: families with a mutation in the presenilin-1 gene (PS-1) on chromosome 14, and fami